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Role identified for glaucoma gene and signaling pathway
Another piece of the puzzle of the mechanism involved in the elevation of IOP has been identified with the discovery of the role of the gene sFRP-1 in the Wnt signaling pathway.
Feature Articles
Ab-interno trabeculectomy with novel ablative device encouraging based on case series outcomes
Direct comparison with standard trabeculectomy is needed, according to physician
Ophthalmology Times
Outcomes data for ab-interno trabeculectomy with a novel ablative device (Trabectome, NeoMedix) to ablate thermally the trabecular meshwork consist of case series. So far, this procedure has been associated with favorable IOP lowering, but a direct comparison with standard trabeculectomy is needed, according to one glaucoma specialist.
Mini glaucoma shunt viable surgical alternative
Compared with trabeculectomy, outcomes showed similar IOP-lowering efficiency
Ophthalmology Times
Surgical outcomes were compared in a retrospective study of 76 eyes with a miniature glaucoma shunt (Ex-PRESS, Optonol) implanted and 77 eyes that underwent standard trabeculectomy. The two procedures were associated with similar IOP-lowering efficacy, but the shunt procedure had a benefit for reducing the risk of hypotony.
Modification minimizes complications of trabeculectomy
Ophthalmology Times
Implantation of a miniature glaucoma device (Ex-PRESS R-50, Optonol) under a scleral flap is a modification of trabeculectomy that appears to provide similar IOP-lowering efficacy but with fewer complications.
Trabecular micro-bypass stent shows favorable safety and efficacy profile
Ab-interno approach avoids conjunctival scarring and a filtering bleb, says physician
Ophthalmology Times
A trabecular bypass micro stent (iStent, Glaukos) was developed to restore fully natural physiologic outflow in glaucomatous eyes by allowing flow of aqueous from the anterior chamber into Schlemm's canal.
Need for accurate, continuous IOP measurements impetus for development of non-contact monitor
Prototype device shows promise in initial performance testing, according to physician
Ophthalmology Times
Current IOP measurement techniques have limited accuracy and do not allow for 24-hour monitoring. A system based on a small, implantable passive transducer and external probe is being developed to address these limitations.
News
Important eye health issues examined in Ophthalmology journal
Ophthalmology Times
Three studies on eye health examine the role of antioxidant supplements, the relationship of visual acuity and mortality, and the causes of glaucoma in the May 2008 issue of Ophthalmology, the journal of the American Academy of Ophthalmology.

Risk of glaucoma increases with diabetes, study supports
Ophthalmology Times
It appears that diabetic retinopathy is not the only eye disease associated with diabetes, according to a study, which found that women with diabetes have about a 70% increased risk of developing the most common form of glaucoma—primary-open angle glaucoma—compared with women without diabetes.
Alcon's Cary Rayment honored as a 'catalyst' for glaucoma work
Commitment to glaucoma research strong after 25 years in eye-care industry
Ophthalmology Times
Cary Rayment, who was honored Jan. 23 by the Glaucoma Research Foundation (GRF) with the 2008 GRF Catalyst Award, is leading his company's strategic plan to spend more than $3.5 billion on research over the next 5 years.
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